For agents to send scan and web reputation queries to the integrated server, File Reputation Services and Web Reputation Services must be enabled. Enabling these services also allows the integrated server to update components from the ActiveUpdate server.
These services are automatically enabled if you chose to install the integrated server during the Apex One server installation.
If you disable the services, be sure that you have installed standalone Smart Protection Servers to which agents can send queries.
For details, see Configuring Integrated Smart Protection Server Settings.