Trend Micro recommends the following strategies for implementing rules and filters
for optimal antivirus and anti-spam protection for a Domino environment:
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Create real-time mail scan rules for all messages and attachments.
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Implement filter rules for unauthorized attachment types and extensions (see the table in Configuring the Attachment Filter for the recommended list).
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Create real-time database scan rules for all databases.
Tip
Consider excluding user mail files (create real-time mail scan rules to scan messages), Domino system databases, and other large size databases that do not change often. This helps allocate server resource to databases that are constantly changing.
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Create a scheduled update rule for antivirus and content security components.
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Create a scheduled database scan rule of all Domino databases.
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Purchase ScanMail Suite for Domino with Data Loss Prevention to implement prevention against unwanted spam or suspicious URL messages.
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Enable comprehensive data loss prevention
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Enable anti-spam protection and specify which actions to take.
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Enable Web Reputation protection and specify which actions to take.
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Set filter levels in accordance with IT security policies.
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Enable and specify approved senders and blocked senders.
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In addition, determine the appropriate number of scan tasks on your system. See Types of Scans for details about the ScanMail scan tasks.