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Common scenarios for handling SMTP traffic

Single Device
Multiple Devices
At the Gateway
The only setup if you plan to use Sender Filtering with the device. IMSVA is deployed at the gateway to provide antivirus, content filtering, spam prevention and Sender Filtering services, which include Network Reputation Services and IP Profiler. See Single IMSVA device at the gateway.
The only setup if you plan to use Sender Filtering with at least one of the devices. You can enable or disable services on different devices. See the following:
Behind the Gateway
The most common setup. IMSVA is deployed between upstream and downstream MTAs to provide antivirus, content filtering and spam prevention services. See Single IMSVA device behind the gateway.
The most common group setup. IMSVA devices are deployed between upstream and downstream MTAs to provide antivirus, content filtering and spam prevention services. You can enable or disable services on different devices. See the following:
Trend Micro Control Manager scenario
If you have multiple groups, you can use Trend Micro Control Manager (TMCM) to manage the devices.
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Single IMSVA device at the gateway
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Single IMSVA device behind the gateway
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IMSVA group at the gateway
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IMSVA group behind the gateway