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Data Loss Prevention monitors network, system, and application channels that can transmit sensitive information.
For a list of supported channels, see the Data Protection Lists document at:

Network Channels

Channel
Description
Email clients
Monitoring occurs when an email client attempts to send an email. Data Loss Prevention checks the email subject, body, and attachments for data identifiers.
FTP
Monitoring occurs when an FTP client attempts to upload files to an FTP server. Data Loss Prevention checks for the presence of data identifiers in the files.
HTTP and HTTPS
Monitoring occurs before data is encrypted and transmitted through HTTP and HTTPS.
IM applications
Monitoring occurs before users send messages or files through instant messaging (IM) applications. Data Loss Prevention does not monitor messages or files that users receive.
SMB protocol
Monitoring occurs when another user attempts to copy or read a user's shared file. Data Loss Prevention checks if the file is or contains a data identifier.
Webmail
Monitoring occurs when a supported web-based email service attempts to transmit data through HTTP. Data Loss Prevention checks the data for the presence of data identifiers.

System and Application Channels

Channel
Description
Cloud storage services
Monitors files that users access using cloud storage services
Data recorders (CD/DVD)
Monitors data recorded to a CD or DVD
PGP Encryption
Monitors data to be encrypted by PGP encryption software. Data Loss Prevention checks the data before encryption proceeds.
Peer-to-peer applications
Monitors files that users share through peer-to-peer applications
Printer
Monitors printer operations initiated from various applications
Data Loss Prevention does not block printer operations on new files that have not been saved because printing information has only been stored in the memory at this point.
Removable storage
Monitors data transmissions to or within removable storage devices
Synchronization software (ActiveSync)
Monitors data transmitted to a mobile device through synchronization software
Windows clipboard
Monitors data to be transmitted to Windows clipboard before allowing or blocking the transmission