You can install the integrated or standalone Smart Protection Server if the number of agents is 1,000 or less. Install a standalone Smart Protection Server if there are more than 1,000 agents.
Trend Micro recommends installing several Smart Protection Servers for failover purposes. Agents that are unable to connect to a particular server will try to connect to the other servers you have set up.
Because the integrated server and the OfficeScan server run on the same endpoint, the endpoint’s performance may reduce significantly during peak traffic for the two servers. Consider using a standalone Smart Protection Server as the primary smart protection source for agents and the integrated server as a backup.