A pure IPv6 agent cannot send queries directly to pure IPv4 sources, such as:
Smart Protection Server 2.0 (integrated or standalone)
IPv6 support for Smart Protection Server starts in version 2.5.
Trend Micro Smart Protection Network
Similarly, a pure IPv4 agent cannot send queries to pure IPv6 Smart Protection Servers.
A dual-stack proxy server that can convert IP addresses, such as DeleGate, is required to allow agents to connect to the sources.