You can choose which lists to enable from those that make up the Standard Reputation database. By default, all lists are enabled. The default setting is the most effective combination for reducing spam levels, and it meets the needs of most customers. You can also use the dynamic reputation slider to adjust how aggressively Email Reputation Services blocks email connections.
If you disable some lists from the Standard database, you may see an increase in the amount of spam messages that reach your internal mail server for additional content filtering.