Download and save to a temporary directory on the [product] server the latest Official Pattern Release (OPR) file:
http://www.trendmicro.com/download/pattern.asp
Or, a Controlled Pattern Release (CPR) file from this location:
http://www.trendmicro.com/download/pattern-cpr-disclaimer.asp
Note: A Controlled Pattern File Release (CPR) is an early release of the virus pattern file. It has been fully tested, and is intended to provide customers with advanced protection against burgeoning threats.
Also from the [product] server, stop all [product] services:
Click the Windows Start button, then Programs > Administrative Tools > Services.
Extract the contents of the compressed file you downloaded to following folder:
\Program Files\Trend Micro\[product]\Utilbin
Restart all the [product] services, then refresh the [product] console.
Update [product] Files Automatically
How Do I Know the Latest Pattern File or Service Pack