To manually update the pattern file (lpt$vpn.xxx):
Download and save to a temporary directory on the ScanMail server the latest Official Pattern Release (OPR) file:
Or, a Controlled Pattern Release (CPR) file from this location:
Note: A Controlled Pattern File Release (CPR) is an early release of the virus pattern file. It has been fully tested, and is intended to provide customers with advanced protection against burgeoning security risks.
Click the Windows Start button, then Programs > Administrative Tools > Services to stop all ScanMail services.
Extract the contents of the compressed file you downloaded to following folder:
\Program Files\Trend Micro\Smex\engine\vsapi\latest
Restart all the ScanMail services, then refresh the ScanMail console.